The Role of PROFHILO® in Contemporary Aesthetic Practice

*Profhilo is among the bio-stimulatory injectables available for aesthetic use.

February 4, 2020

Those in their quest for maintaining youthful, vibrant skin often find it hard to do so simply by taking topical and oral supplements.

While there is no doubt that a healthy diet and regular exercise is the key to amazing skin – there is only so much that one can do with a hectic schedule.

Before, there was plastic surgery – but patients are now looking for less invasive treatments, or in-office “tweakments” that require minimal downtime –essentially achieving much more, with less.

Advancements in technology have led to the development of improved injectable treatments, offering more natural-looking results compared to the overly puffy appearances sometimes associated with traditional fillers and Botox in the past.

One such treatment is Profhilo, an injectable treatment that has been discussed in medical and aesthetic research, as well as media publications.

Profhilo for Skin Hydration and Elasticity: What to Know

Profhilo is a patented injectable treatment designed to support skin rejuvenation. It was developed by Swiss biologists with extensive experience in pharmaceutical research and technology, particularly in hyaluronic acid (HA) formulations.

It is known that the secret to youthful, vibrant skin is the presence of collagen, elastin and adipocytes – vital substances that start to decrease as we age.

This leads to the emergence of the major symptoms of skin ageing, including wrinkles, skin laxity and tired, lacklustre skin.

A potent ingredient that can help to replenish and promote collagen synthesis in the skin and body is HA – a humectant that attracts and holds up to 1,000 times its own weight in hydration!

The problem is – most HA-based products used in aesthetic medicine are based on chemical cross-linking that, although does the job – often changes and modifies the behaviour of HA – something that is counterproductive and not ideal.

Profhilo differs itself through its patented bio-remodelling technology, which avoids chemical cross-linking entirely. This approach allows for optimal integration with the skin’s biology, supporting natural rejuvenation without artificial modifications.

The Characteristics of Profhilo

Profhilo contains a high concentration of hyaluronic acid (HA) (64mg/2ml), consisting of 32mg low molecular weight HA (L-HA) and 32mg high molecular weight HA (H-HA). This formulation uses NAHYCO® Technology to create a stabilised Hybrid Cooperative Complex HA.

Don’t be confused just yet – what this means is that the composition contributes to its stability and longevity – acting to stimulate collagen and elastin in the body to improve skin laxity.

In addition, the purified hyaluronic acid (HA) formulation in Profhilo is approved for cosmetic injectable use. Clinical studies have demonstrated its safety profile for this treatment.

What Profhilo does

Profhilo is designed to support skin hydration and contributes to tissue remodelling in multiple layers of the face. Its formulation demonstrates favourable spreadability and a low inflammatory potential, which are factors that influences treatment experience2.

Rather than filling your face in specific areas, or disabling facial muscles – Profhilo works with your tissues to stimulate positive reactions throughout your natural skin renewal cycle.

What Profhilo doesn’t do

Despite the plethora of benefits that Profhilo offers – it is important to note that it is primarily a bio-remodelling injectable, and should not be considered as an alternative to traditional fillers. If you are looking to plump up your face or dramatically alter the structure of your face – you are still better off using dermal fillers.

Treatment Method and Expected Outcomes

Profhilo utilises the BAP (Bio Aesthetic Points) technique, involving 5 injection points per facial side. This technique aims to distribute hyaluronic acid (HA) across facial tissues, which supports collagen and elastin production while maintaining hydration.

Clinical studies have shown that when administered using the BAP technique, Profhilo contributes to improved facial volume, skin elasticity and hydration3. The study also indicates these effects become noticeable after one to two treatment sessions4.

The treatment protocol typically involves 2 sessions spaced 1-month apart. As the HA is gradually metabolised, results develop progressively rather than immediately.

Profhilo can be combined with other aesthetic procedures, such as laser treatment for surgical scars, as part of a comprehensive scar management approach.

References.
1. Rodriguez Abascal M. et al. Facial bioremodeling by intradermal injection of a stabilized hybrid complex of high and low molecular weight hyaluronic acid: prospective study on 30 patients. Eur Aesth Plast Surg J 2015; 5(2): 124-131.
2. Laurino C, Palmieri B, Coacci A. Efficacy, safety, and tolerance of a new injection technique for high- and low-molecular-weight hyaluronic acid hybrid complexes. Eplasty. 2015;E46:427–437.
3. Sparavigna A, Tenconi B: Efficacy and tolerance of an injectable medical device containing stable hybrid cooperative complexes of high- and low-molecular-weight hyaluronic acid: a monocentric 16 weeks open-label evaluation. Clin Cosmet Investig Dermatol 2016; 9: 297-305.
4. Beatini A. et al. Hyaluronic acid hybrid cooperative complexes and the BAP (Bio Aesthetic Points) technique: the new edge in biorejuvenation. Aesthetic Medicine 2016; 2(2).

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