Does Chemotherapy Cause Skin Problems? What To Expect & Manage

When we hear the word chemotherapy, the first image that often comes to mind is hair loss. It’s one of the most visible and well-known side effects of cancer treatment, and for many, it symbolises the journey of battling cancer. People may even prepare emotionally for this change before starting treatment because it is such a common association.

Yet, hair is not the only aspect of our appearance that chemotherapy can affect. While it’s true that many people anticipate hair loss, fewer expect the changes that may occur in their skin. In fact, skin is often just as affected as hair and nails during chemotherapy, but it tends to get less attention. These changes can be frustrating, sometimes uncomfortable, and may impact confidence during an already challenging period.

Why chemotherapy affects the skin

Chemotherapy drugs are designed to target and destroy rapidly dividing cancer cells. Unfortunately, they can also affect other fast-growing cells in the body, including those in the skin¹. As skin cells constantly renew themselves, the effects of chemotherapy can disrupt this process, leading to noticeable changes.

The type and severity of skin issues vary from person to person. Some may only experience mild dryness, while others could face more noticeable conditions that require medical attention. The important thing to remember is that these changes are not unusual; they’re part of the way chemotherapy interacts with the body.

Common chemotherapy-related skin problems

Dryness and itching

One of the most common side effects is dry, flaky skin. Chemotherapy can reduce the skin’s natural oils, making it feel rough, tight, or itchy. Some people may notice small cracks, especially around the hands and feet, which can be uncomfortable².

Sensitivity and rashes

Skin may also become more sensitive to external factors like sunlight, fragrances, or certain fabrics. Some chemotherapy drugs are known to trigger rashes that resemble acne or cause redness and irritation in specific areas. These reactions can sometimes look alarming, but they are usually manageable with proper care.

Pigmentation changes

Discolouration, such as darkened patches on the skin, can occur during treatment. This may be more noticeable on the hands, nails, or areas exposed to the sun. While pigmentation changes are usually temporary, they can be distressing for patients who are already coping with physical and emotional changes.

Nail and cuticle issues

Though not strictly skin, nails and the surrounding cuticles can also be affected. Chemotherapy may cause nails to become brittle, ridged, or discoloured. Some people even experience tender, inflamed cuticles.

Hand-foot syndrome

Certain chemotherapy drugs can cause a condition known as palmar-plantar erythrodysesthesia, or “hand-foot syndrome”². This results in redness, swelling, and pain in the palms of the hands and soles of the feet. In more severe cases, blisters may form, making everyday activities difficult.

Managing skin problems during chemotherapy

Taking care of your skin during chemotherapy doesn’t have to be complicated. Simple, consistent routines can make a big difference in reducing discomfort and helping you feel more at ease in your own skin.

1. Keep skin hydrated

Moisturising is key. Choose fragrance-free, hypoallergenic creams or ointments that provide long-lasting hydration. Applying them after bathing helps lock in moisture. Products containing ceramides, glycerin, or shea butter are particularly effective.

2. Be gentle with cleansing

Avoid harsh soaps or scrubs. Instead, use mild, soap-free cleansers that don’t strip the skin of natural oils. Showers should be lukewarm rather than hot, as heat can dry the skin further.

3. Protect from the sun

Skin undergoing chemotherapy can be more sensitive to sunlight. Applying a broad-spectrum sunscreen with SPF 50 or higher, wearing protective clothing, and seeking shade during peak hours can prevent sunburn and pigmentation changes.

4. Avoid irritants

Perfumed products, alcohol-based skincare, and rough fabrics can aggravate sensitive skin. Switching to gentle laundry detergents and using cotton clothing can help minimise irritation.

5. Look after nails

Keeping nails trimmed and filed reduces the risk of breakage. A nourishing hand cream, applied regularly, can keep cuticles soft and prevent painful cracks. Wearing gloves during household chores adds another layer of protection.

6. Speak to a specialist

Not all skin issues can be solved at home. If rashes, severe itching, or painful conditions like hand-foot syndrome appear, it’s best to consult a dermatologist. For example, those seeking dermatology in Singapore will find that specialists can provide targeted treatments to ease symptoms, protect skin health, and improve overall comfort during chemotherapy.

Emotional impact of skin changes

Beyond the physical discomfort, skin changes can affect how someone feels about themselves. Visible rashes, pigmentation shifts, or cracked skin may lower confidence, especially when combined with other chemotherapy side effects such as hair loss. For some, these changes act as a daily reminder of their illness, which can be emotionally draining.

This is why self-care and emotional support are just as important as physical care. Taking small steps to protect your skin can help restore a sense of control. Equally, being open with friends, family, or support groups about these challenges can make the journey feel less isolating.

What to expect after treatment

The good news is that many chemotherapy-related skin changes are temporary. As treatment ends and the body begins to recover, the skin gradually heals. Moisture levels often return, rashes fade, and pigmentation usually lightens over time.

Some people also experience what’s known as post-chemo hair recovery, which goes hand-in-hand with overall improvements in skin and nail health. While patience is required, the body has a remarkable ability to bounce back once chemotherapy is complete.

For those who continue to experience ongoing skin issues after treatment, consulting a dermatologist remains a wise choice. Specialists can recommend treatments to improve skin texture, restore pigmentation balance, and address any long-term changes.

Living well during chemotherapy

Coping with chemotherapy is no small feat. Between the emotional rollercoaster and the physical toll, small acts of self-care can provide comfort and resilience. Simple skincare routines, protective measures, and professional guidance where needed can make a difference.

Even though skin issues might not be the first thing people think about when starting chemotherapy, knowing what to expect and how to manage it helps patients feel more prepared. Understanding that these changes are normal, manageable, and often temporary provides reassurance during a difficult time.

Conclusion

Chemotherapy can bring many challenges, including changes to the skin that may feel overwhelming. From dryness and sensitivity to pigmentation and nail issues, these side effects are part of how the treatment interacts with the body. With the right skincare habits, protective measures, and professional support, they can be managed effectively.

For expert advice and personalised care, Angeline Yong Dermatology offers cosmetic, surgical, and medical treatments tailored to your needs, ensuring you receive comprehensive support throughout your journey.

References

Chemotherapy. American Cancer Society. (n.d.). https://www.cancer.org/cancer/managing-cancer/treatment-types/chemotherapy.html

Your skin, nails and cancer drugs. Treatment for cancer | Cancer Research UK. (2024, November 14). https://www.cancerresearchuk.org/about-cancer/treatment/cancer-drugs/side-effects/skin-nails

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Does Chemotherapy Cause Skin Problems? What To Expect & Manage