The Link Between DHT And Hair Loss: What You Need To Know

Hair loss can feel like an unwelcome companion, affecting both men and women at various stages of life. While it’s common knowledge that ageing often brings about thinning hair, many people are unaware of the underlying biological causes that lead to hair shedding or balding. For most, the conversation stops at genetics or stress without exploring the root mechanisms.

Among these mechanisms, dihydrotestosterone (DHT) is a significant player. This androgen hormone, derived from testosterone, is often linked to hair loss patterns in both genders. Understanding DHT’s role can help you make informed decisions about preventing or addressing hair thinning. Below, we explore this lesser-discussed topic to better understand its causes and what can be done about it.

What is DHT?

DHT is a hormone formed when testosterone interacts with an enzyme called 5-alpha reductase¹. While DHT is vital in developing male characteristics like a deep voice and facial hair during puberty, it can have unintended effects later in life. In adults, DHT binds to hair follicles², shrinking them over time and leading to a condition called follicular miniaturisation.

Follicular miniaturisation causes hair to grow finer, weaker, and shorter until the follicle eventually stops producing hair altogether. This process is most commonly seen in male pattern baldness (androgenetic alopecia) but can also affect women. The result? Thinning hairlines, balding crowns, and a lot of frustration.

Why does DHT affect hair?

The connection between DHT and hair lies in the sensitivity of your hair follicles. Some individuals inherit a genetic predisposition that makes their follicles more sensitive to DHT. Once DHT binds to these susceptible follicles, it disrupts the natural hair growth cycle, shortening the growth phase (anagen) and prolonging the resting phase (telogen)³.

Over time, DHT damages the follicles so significantly that they can no longer produce healthy hair strands. While this phenomenon is more pronounced in men, women can also experience hair thinning due to hormonal fluctuations or conditions like polycystic ovary syndrome (PCOS), which increases DHT levels.

Identifying DHT-related hair loss

How can you tell if your hair loss is related to DHT? Here are some common signs:

Receding hairline: This is a classic sign in men, where the hairline moves back, forming an “M” shape.
Thinning at the crown: A gradual loss of density at the top of the scalp is another hallmark.
Widening central partline and diffuse thinning in women: Women may notice a widening of the central partline but also a general reduction in hair density across the scalp rather than specific bald spots.

Consulting a dermatologist can help confirm whether DHT is the culprit. A dermatology clinic can provide diagnostic tests, such as blood work or scalp biopsies where needed to identify underlying hormonal imbalances or hereditary factors.

Managing DHT levels

The good news? You can take steps to manage DHT levels and minimise its effects on your hair. Here are a few popular methods:

1. DHT blockers

DHT blockers are medications or topical treatments that prevent DHT from binding to hair follicles. Finasteride and dutasteride, for instance, inhibits the 5-alpha reductase enzyme, reducing DHT production. Minoxidil, though not a DHT blocker, helps stimulate hair growth, prolongs the anagen growth phase of hair follicles, and improves follicle health⁴.

2. Lifestyle changes

Diet and lifestyle can influence your hormone levels. Foods rich in zinc, biotin, and omega-3 fatty acids may promote hair health. Additionally, stress management techniques like mindfulness or yoga can prevent hormonal imbalances that worsen hair loss.

3. Medical procedures

For advanced cases of hair loss, procedures like Follicular Unit Extraction (FUE) can be effective. Many individuals choose FUE hair transplant for hair restoration, as it offers natural-looking results with minimal scarring.

4. Natural remedies

While not as potent as medical treatments, natural remedies like pumpkin seed oil, saw palmetto, or green tea extracts have shown some promise in blocking DHT and supporting healthy hair growth.

The emotional impact of hair loss

Hair is often tied to one’s identity and confidence, so hair loss can take a significant emotional toll. Feelings of self-consciousness, frustration, or even depression are not uncommon. That’s why seeking professional help is important – not only for treatment but also for support and guidance.

Dermatologists understand that hair loss isn’t just a cosmetic issue. It’s a condition that can affect your mental well-being. Visiting a trusted dermatology clinic ensures you receive both the physical and emotional care you need.

Conclusion

Hair loss may feel like a losing battle, but understanding the role of DHT opens up new possibilities for prevention and treatment. If you’re struggling with hair thinning or balding, it’s crucial to take action early and seek expert advice.

At Angeline Yong Dermatology, we offer a comprehensive range of dermatological services tailored to each individual. Take the first step toward healthier hair and skin – schedule a consultation today.

References

5-alpha reductase deficiency: MedlinePlus Genetics. (n.d.). https://medlineplus.gov/genetics/condition/5-alpha-reductase-deficiency/#:~:text=Specifically%2C%20the%20steroid%205%2Dalpha,formation%20of%20the%20external%20genitalia

Vanta, B. (2023, September 25). Hair miniaturization (A sign of androgenic alopecia) – HairScience. HairScience. https://hairscience.org/news/hair-miniaturization/

Ustuner E. T. (2013). Cause of androgenic alopecia: crux of the matter. Plastic and reconstructive surgery. Global open, 1(7), e64. https://doi.org/10.1097/GOX.0000000000000005

Jewell, T. (2024, July 31). What you need to know about DHT and hair loss. Healthline. https://www.healthline.com/health/dht#testosterone

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The Link Between DHT And Hair Loss: What You Need To Know